The relationship between cognitive function and the enlargement of peripheral vascular space in patients with acute ischemic stroke
10.3760/cma.j.cn371468-20200324-01165
- VernacularTitle:急性缺血性卒中患者认知功能与血管周围间隙扩大的相关性
- Author:
Xiangyu LI
1
;
Zhenjie TENG
;
Xiaosha LI
;
Yifan JI
;
Peiyuan LYU
Author Information
1. 河北医科大学研究生学院，石家庄 050017；河北省人民医院神经内科，石家庄 050051
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(8):736-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the enlarged of peripheral vascular space and cognitive function in patients with acute ischemic stroke.Methods:Totally 223 patients with first-episode acute cerebral infarction were selected from the department of neurology in Hebei general hospital from September 2016 to December 2018, who completed the test of cognitive function. All patients were divided into cognitive impairment group( n=67)and normal cognitive group( n=156)according to the score of MoCA.The risk factors of cognitive function and the relationship between the enlargement of perivascular space and cognitive function were analyzed by SPSS 21.0. Results:Age, history of coronary heart disease, Hcy, Fib, BG-EPVS and CSO-EPVS were statistically significant different in cognitive impairment group and normal cognitive group(all P<0.05). Age ( B=0.067, OR=1.070, 95% CI=1.035-1.106, P<0.05), Hcy( B=0.032, OR=1.033, 95% CI=1.007-1.060, P=0.013), and BG-EPVS( B=0.720, OR=2.055, 95% CI=1.041-4.055, P=0.038)were independent risk factors for cognitive impairment.The degree of BG-EPVS in the cognitive impairment group was negatively correlated with the total MoCA score( r=-0.332, P<0.05), visual space and execution( r=-0.256, P<0.01), attention( r=-0.256, P<0.01), language( r=-0.182, P<0.05)and orientation( r=-0.370, P<0.05). Conclusion:EPVS, especially BG-EPVS, can be used as an indicator to evaluate the early cognitive function of AIS patients.
