The Roles of Innate Lymphoid Cells in the Development of Asthma.

Author: Yeonduk WOO ¹ ; Dongjin JEONG ; Doo Hyun CHUNG ; Hye Young KIM
Author Information

1. Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-744, Korea.
Publication Type:Review
Keywords: Airway hyperreactivity; Asthma; Innate lymphoid cells; Allergic asthma; Non-allergic asthma
MeSH: Adaptive Immunity; Air Pollution; Asthma*; Cytokines; Immune System; Interleukin-5; Lung Diseases; Lymphocytes*; Macrophages; Natural Killer T-Cells; Neutrophils; Obesity; Th2 Cells
From:Immune Network 2014;14(4):171-181
CountryRepublic of Korea
Language:English
Abstract: Asthma is a common pulmonary disease with several different forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in association with allergen sensitization and adaptive immunity. Recently, there have been many advances in understanding non-allergic asthma, which seems to be related to environmental factors such as air pollution, infection, or even obesity. Cells of the innate immune system, including macrophages, neutrophils, and natural killer T cells as well as the newly described innate lymphoid cells, are effective producers of a variety of cytokines and seem to play important roles in the development of non-allergic asthma. In this review, we focus on recent findings regarding innate lymphoid cells and their roles in asthma.