Integration of the Innate and Adaptive Immunity by CD137-CD137L Bidirectional Signals: Implications in Allograft Rejection.
10.4285/jkstn.2014.28.3.113
- Author:
Sang June PARK
1
;
Jong Soo LEE
;
Byungsuk KWON
;
Hong Rae CHO
Author Information
1. Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. hrcho@uuh.ulsan.kr
- Publication Type:Review
- Keywords:
Costimulation;
CD137;
CD137L;
Immune response
- MeSH:
Adaptive Immunity*;
Allografts*;
Memory;
Rodentia;
T-Lymphocytes
- From:The Journal of the Korean Society for Transplantation
2014;28(3):113-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
Two-signal models are useful in explaining various types of immune responses. In particular, secondary, so-called costimulatory, signals are critically required for the process of T-cell activation, survival, differentiation, and memory formation. Early studies in rodent models showed that targeting T-cell costimulatory pathways elicits immunological tolerance, providing a basis for development of costimulatory therapeutics in allograft rejection. However, as the classic definition of T-cell costimulation continues to evolve, simple blockade of costimulatory pathways has limitations in prevention of allograft rejection. Furthermore, functions of costimulatory molecules are much more diverse than initially anticipated and beyond T cells. In this mini-review, we will discuss CD137-CD137L bidirectional signals as examples showing that two-signals can be applicable to multiple phases of immune responses.
