The characteristics of degree centrality and voxel-mirrored homotopic connectivity in patients with obsessive-compulsive disorder
10.3760/cma.j.cn371468-20190921-00658
- VernacularTitle:强迫症患者静息态功能磁共振度中心度和镜像同伦连接特点
- Author:
Wenjing TONG
1
;
Xianrui LI
;
Haisan ZHANG
;
Yongfeng YANG
;
Kun LI
;
Meng ZHANG
;
Bi WANG
;
Siyuan LI
;
Luxian LYU
;
Hongxing ZHANG
Author Information
1. 新乡医学院心理学院 453003
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(5):442-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the functional connections of the whole brain and the two hemispheres in patients with obsessive-compulsive disorder (OCD).Methods:Twenty-six patients with obsessive-compulsive disorder(patients group) and thirty-seven healthy controls matched in gender, age and education(control group) were enrolled.All the participants accepted the resting-state functional magnetic resonance (rs-fMRI) scan.Based on DPABI and REST software, degree centrality (DC) and voxel - mirrored homotopic connectivity (VMHC) approaches were used to explore the pattern of functional connection in OCD.Results:Compared with the control group, the DC values in the right posterior cerebellar lobe(MNI: x, y, z=45, -87, -12), left precentral gyrus(MNI: x, y, z=-54, 9, 39), left inferior parietal lobule(MNI: x, y, z=-48, -51, 42), right anterior cingulate cortex(MNI: x, y, z=3, 18, 48) were significantly higher( t values were 5.75, 5.26, 5.28 and 5.16, respectively), and the DC values in the left inferior frontal gyrus(MNI: x, y, z=-36, 9, 30) were significantly lower( t value was -6.65) in patients group.The VMHC values in bilateral posterior cerebellar lobe(MNI: x, y, z=±51, -69, -33), bilateral inferior parietal lobule(MNI: x, y, z=±48, -51, 54), bilateral anterior cingulate cortex(MNI: x, y, z=±3, 21, 45)in patients group were significantly higher that those in control group( t values were 5.19, 5.19, 5.02, 5.02, 5.15 and 5.15, respectively). The DC and VMHC values in patients group were not significantly correlated with clinical symptoms(-0.23< r<0.19, P>0.05). Conclusion:OCD patients have abnormal connections between key brain network nodes and relevant brain regions, and functional connections have increased among multiple cerebral hemispheres.
