Research progress of immune regulation in antidepressant treatment
10.3760/cma.j.cn371468-20191204-00885
- VernacularTitle:免疫调节抗抑郁治疗研究进展
- Author:
Peilin WANG
1
;
Nan ZHANG
;
Simeng MA
;
Zhongchun LIU
Author Information
1. 武汉大学人民医院精神卫生中心 430060
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the role of inflammation in depression has received people's attention.Studies have suggested that immune disorder may play an important role in depression, and patients with depression exhibit characteristic immunophenotypes.Inflammation seems to interact with a variety of pathogenesis of depression.Therefore, immunoregulation is becoming an adjuvant therapy for depression.Clinically, not only antidepressants show anti-inflammatory effects, but also anti-inflammatory drugs show antidepressant effects, and they mainly including non-steroidal anti-inflammatory drugs, statins, and cytokine inhibitors.In addition, some non-drug treatment methods are also given immunomodulatory effects, such as electric shock therapy, vagus nerve stimulation, acupuncture and exercise therapy.However, there are still some problems in immunomodulation therapy, such as immunomodulation therapy may be only effective for some subgroups of patients, and its efficacy and safety need to be evaluated.In the future, looking for more effective biomarkers and identifying immune-inflammation-related subtype of depression, will serve to explore new diagnosis and treatment strategies.
