Correlation analysis between executive dysfunction and serum glial-derived neurotrophic factor level in children with attention deficit/hyperactivity disorder
10.3760/cma.j.cn371468-20190606-00372
- VernacularTitle:注意缺陷多动障碍患儿执行功能与血清胶质源性神经营养因子水平的相关性
- Author:
Na LIU
1
;
Yan SANG
;
Jiao CHEN
;
Xiaoming LIU
Author Information
1. 徐州医科大学附属徐州儿童医院神经内科 221002
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(1):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between executive dysfunction and serum glial-derived neurotrophic factor (GDNF) levels in children with attention deficit hyperactivity disorder (ADHD).Methods:32 drug-free ADHD patients and 34 normal children matched in gender, age and IQ were included.The executive function was assessed using Digital Span Back Test (DSB-T), Trail Making Test (TMT), Semantic Fluency Test (SFT) and Stroop Color Word Test (SCW-T), and peripheral GDNF levels were measured by the enzyme linked immunosorbent assay (ELISA). The executive functional test scores and serum GDNF levels were compared between groups, and then the correlation between executive dysfunction and GDNF was analyzed by Spearman or pearson correlation analysis.Results:(1) In the ADHD group, the DSB-T and SFT scores were lower than those in the normal control group(DSB-T4: (2) vs 5(1); SFT(13.66±2.34) vs (15.21±2.13)( Z=3.16, t=2.82, both P<0.05) and the TMT-A and TMT-B time-consuming were higher than those in the normal control group(TMT-A(61.12±19.03)s vs (48.76±21.06)s; TMT-B(158.66±63.78)s vs (123.62±45.24)s, t=2.50, 2.59, both P<0.05). The Word color consumption, word interference and word color errors of SCW-T in ADHD group were higher than those in the normal control group(Word color consumption(56.41±21.65)s vs (45.97±13.42)s; word interference 27(25)s vs 20(15)s; word color errors 4(3) vs 2(1)), and the differences were statistically significant( t=2.37, Z=2.31, 2.11, all P<0.05). (2) Serum levels of GDNF in the ADHD group were lower than that in the normal control group((481.59±68.74)pg/ml vs (552.47±110.13)pg/ml) , and the difference was statistically significant ( t=3.11, P<0.05). (3) In the ADHD group, serum GDNF levels were negatively correlated with TMT-A, TMT-B and SCW-T word interference performance ( r=-0.512, r=-0.578, r=-0.432, all P<0.05), and positively correlated with DSB-T performance( r=0.381, P<0.05). Conclusion:Executive function is extensively damaged in ADHD patients, and GDNF may be involved in the pathophysiology of executive impairment.
