Research on the signal pathway of hydrogen sulfide regulating autophagy to protect intestinal injury in sepsis
10.3760/cma.j.cn121430-20200723-00249
- VernacularTitle:H 2S调节自噬保护脓毒症肠损伤信号通路的研究进展
- Author:
Jingyun NIE
1
;
Fugui KANG
;
Chenhan ZHANG
;
Chen CHAI
;
Man HE
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- From:
Chinese Critical Care Medicine
2020;32(10):1277-1280
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is one of the main causes of death in critically ill patients. The intestinal tract is not only the organ easily involved in sepsis, but also the initial organ in the progression of sepsis, so the improvement of intestinal barrier function is the key of the treatment of sepsis. In recent years, it has been found that autophagy is involved in the pathological process of sepsis, maintaining mitochondrial function by clearing damaged organelles, inhibiting inflammation, oxidative stress and apoptosis, regulating immunity, maintaining intestinal homeostasis, and improving the condition and prognosis of sepsis. It is an effective target for the treatment of sepsis. As a new type of medical gas signal molecule, hydrogen sulfide (H 2S) can regulate autophagy by regulating multiple signal pathways, which has become a new target in the treatment of sepsis. This article reviews the signal pathway regulation mechanism of H 2S regulating autophagy in septic intestinal dysfunction.
