Establishment of animal model of ischemic acute kidney injury
10.3760/cma.j.cn121430-20200417-00309
- VernacularTitle:缺血性急性肾损伤动物模型制备的研究进展
- Author:
Ling WU
1
;
Ting JIANG
;
Anqi TANG
;
Liangbin ZHAO
;
Mingquan LI
Author Information
1. 成都中医药大学附属医院肾病二科，成都 610072
- From:
Chinese Critical Care Medicine
2020;32(9):1149-1152
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury (AKI) is a common clinical critical illness, and ischemic kidney injury is the main type. The mortality rate of ischemic kidney injury is high, because the efficacy of treatment is limited due to symptomatic and supportive treatment. Establishing a reliable animal model of ischemic AKI is an important prerequisite for conducting research on physiological, pathological and pharmacological researches, so as to explore effective prevention methods and strategies. In recent years, the establishment methods of animal models of ischemic AKI have been continuously improved. The article summarizes the common methods and model characteristics of animal models of ischemic AKI in order to provide a reference for researchers to choose a reasonable modeling method.
