2019 Novel coronavirus, renin-angiotension system imbalance and coronavirus disease 2019
10.3760/cma.j.cn121430-20200312-00159
- VernacularTitle:2019新型冠状病毒和肾素-血管紧张素系统失衡与新型冠状病毒肺炎
- Author:
Yipeng FANG
1
;
Zhe GUO
;
Yan CHAI
;
Huijuan ZHANG
;
Zhong WANG
Author Information
1. 清华大学临床医学院，北京 100084
- From:
Chinese Critical Care Medicine
2020;32(5):613-617
- CountryChina
- Language:Chinese
-
Abstract:
2019 Novel coronavirus (2019-nCoV) destroys angiotensin converting enzyme 2 (ACE2) and breaks the balance of renin-angiotension system (RAS) by interacting with ACE2. The imbalance of RAS takes part in the development of organ injury of different systems through pro-inflammation, oxidative stress, cell proliferation and so on. 2019-nCoV not only attacks the lung, but also influences many other systems. It is speculated that RAS imbalance plays an important role in the development of multi-organ dysfunction caused by 2019-nCoV, and the usage of angiotensin converting enzyme inhibitor/angiotensin Ⅱ receptor blocker (ACEI/ARB) may become a new treatment of 2019-nCoV-related organ injury. Further studies are need to confirm the relationship between coronavirus infection, multi-organ injury and RAS imbalance.
