A successfully treated case of colchicine poisoning with lethal dose

VernacularTitle:致死剂量秋水仙碱中毒成功救治1例
Author: Yuxia SUN ¹ ; Yulong YAO ; Kailiang XU ; Lin YUAN ; Gang CHEN ; Weifang YUAN ; Ming LEI
Author Information

1. 上海中医药大学附属第七人民医院重症医学科，上海　200137
From: Chinese Critical Care Medicine 2020;32(2):240-242
CountryChina
Language:Chinese
Abstract: At present, there is no specific antidote for colchicine intoxication, and 0.8 mg/kg is its lethal dose.The prognosis of colchicine intoxication patients is closely related to the dosage, but the individual difference is very great. A 38-year-old man with colchicine poisoning was admitted to the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, who had ingested 80 mg colchicine tablets (1.19 mg/kg) orally for 4 hours. He was immediately put on gastric lavage, enema, and catharsis. Continuous blood purification was performed for 34 hours and 22 minutes, with a combination of hemoperfusion (HP) and continuous veno-venous hemofiltration dialysis (CVVHDF). He also received a large dose of the glucocorticoid with 80 mg of methylprednisolone injected intravenously every 8 hours and organ function support. The patient was hospitalized for 2 weeks and discharged with improvement. The successful treatment of this case was reported for reference.