A systematic review of methodology in clinical trial-based health economics study with cost-effectiveness ratio for nutritional drug in T3 transfer of translational medicine
10.3760/cma.j.cn115822-20191120-00171
- VernacularTitle:营养用药T3转化-临床研究为基础的成本效果分析
- Author:
Zhuo LI
1
;
Sheng HAN
;
Zhuming JIANG
;
Hai FANG
;
Yang WANG
;
Jiuhong WU
;
Hui ZHANG
;
Yan WANG
;
Xiaomeng LI
;
Xianna ZHANG
;
Kang YU
;
Weiming KANG
;
Wei LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院健康医学系临床营养科 100730
- From:
Chinese Journal of Clinical Nutrition
2020;28(2):65-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review the methodology in clinical trial-based health economics study with cost-effectiveness ratio for nutritional drug.Methods:The literature on health economics study for nutritional drug was retrieved from PubMed and Wanfang Medical Network by October 2019. The literature was selected according to inclusion and exclusion criteria, and was assessed using the Cochrane Risk Bias Assessment Tool and Newcastle-Ottawa Scale. Its methodology such as participants and grouping, confounding factors, research perspective, cost accounting, health outcomes and health economics analysis methods, sensitivity analysis, etc, was systematically reviewed as well.Results:Four target literatures were included in this study. The participants were from gastroenterology, gastrointestinal surgery, etc. Random grouping, regression, propensity score matching method, etc, were used to control confounding factors. The research perspective needed to be clear according to the principle of health economics study. The present literatures focused on "direct medical costs" , and calculated cost-effectiveness ratio or incremental cost-effectiveness ratio to evaluate the economics of medical interventions.Conclusion:The evidence of high-quality health economics research in parenteral and enteral nutrition area in China needs to be promoted, especially in the control of confounding factors, the choice of research perspective and sensitivity analysis, which are supposed to be explored by multidisciplinary research teams in practice.
