Research progress on the effects of hypoglycemic drugs on the composition and regulation of nutrition and metabolism of gut microbiota
10.3760/cma.j.cn115822-20200225-00040
- VernacularTitle:降糖药物对肠道菌群的构成及其营养代谢调节影响的研究进展
- Author:
Shixuan LIU
1
;
Tao YUAN
;
Yong FU
;
Yingyue DONG
;
Weigang ZHAO
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科，国家卫生健康委员会内分泌重点实验室 100730
- From:
Chinese Journal of Clinical Nutrition
2020;28(2):118-124
- CountryChina
- Language:Chinese
-
Abstract:
Gut microbiota is considered as the cornerstone of maintaining the health of human host, because it not only helps to obtain nutrition and energy from the food, but also regulates the energy metabolism through the metabolites produced, which plays an important role in the occurrence and development of various metabolic diseases. In recent years, with the development of science and technology, hypoglycemic treatment has been gradually promoted, safer and more efficient hypoglycemic drugs have been emerging, including sulfonylureas, biguanides, glinides, α-glucosidase inhibitors, dipeptidyl peptidase Ⅳ inhibitors, glucagon like peptide-1 receptor agonists, sodium glucose cotransporter 2 inhibitors and various types of insulin preparations. A large number of studies have proved that intestinal flora may be one of the targets for hypoglycemic drugs to control blood glucose. In this article, we aim to review the effects of hypoglycemic drugs on the composition of intestinal flora and the regulation of nutrition and energy metabolism, and provide reference for future researches on mechanism and target of new antidiabetic drugs.
