The effect of oral nutrition supplementation on the nutritional status of children with primary acute lymphoblastic leukemia during chemotherapy
10.3760/cma.j.cn115822-20200226-00041
- VernacularTitle:口服营养补充对改善初发急性淋巴细胞白血病患儿化疗期营养状况的作用初探
- Author:
Jun FEI
1
;
Xiaoyan ZHANG
;
Zhuoqi ZHAO
;
Yi FENG
;
Li HONG
;
Liya PAN
Author Information
1. 上海交通大学医学院附属上海儿童医学中心临床营养科 200127
- From:
Chinese Journal of Clinical Nutrition
2020;28(2):72-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to survey the changes of the nutritional status of the children with primary acute lymphoblastic leukemia (ALL) using L-asparaginase (L-Asp) and evaluate the effect of Oral nutritional supplements (ONS) added high protein and medium-chain triglyceride (MCT)(FSMP) improving their nutritional status and clinical outcome.Methods:121 ALL patients receiving the L-Asp chemotherapy were randomized administered conventional low-fat formula (control group, 63 cases) and high protein and MCT FSMP (intervention group, 58 cases). We recorded the one-week diet and performed dietary analysis. The changes of body weight and albumin were recorded on admission and discharge, and the body composition was determined, the nutritional status, number of hospitalization days, and medical costs were assessed.Results:ALL patients had lower intake than the guideline′s recommended value during chemotherapy. The control group was significantly lower in calorie intake and nutrients intake than the intervention group. Weight changes during chemotherapy were positivelycorrelated with calorie intake ( P=0.009), protein intake( P=0.014), and carbohydrate intake( P=0.003). Conclusions:ALL children have different degrees of weight loss and protein level decline during chemotherapy, and their nutritional status was closely related to nutritional intake.ONS is an important nutritional therapy. The appropriate addition of high protein and MCT FSMP can alleviate the loss of thin body weight and the decline of albumin in ALL children.
