Changes and clinical significance of Th1/Th2 cytokines in peripheral blood of children with mycoplasma pneumoniae pneumonia
10.3760/cma.j.issn.1008-6706.2020.24.016
- VernacularTitle:儿童肺炎支原体肺炎外周血中Th1/Th2细胞因子变化及临床意义
- Author:
Xianjin YAO
1
;
Jielin ZHOU
;
Zhuying ZHOU
Author Information
1. 杭州市儿童医院儿科 310014
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(24):3015-3018
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes and clinical significance of Th1/Th2 cytokines in peripheral blood of children with mycoplasma pneumoniae pneumonia(MPP).Methods:The clinical data of 60 MPP children who were treated in the hospital from January 2016 to February 2020 were retrospectively analyzed.According to disease progression, MPP children were divided into acute period group( n=29) and recovery period group( n=31). Another 50 healthy children who underwent physical examination in the hospital during the same period were enrolled as healthy control group.The levels of interleukin 4(IL-4) and γ-interferon(IFN-γ) were detected by double sandwich antibody ELISA. Results:The levels of IFN-γ and IL-4 in the acute period group[(1 235.24±254.64)ng/L, (781.13±113.09)ng/L] were significantly higher than those in the recovery period group[(545.38±58.57)ng/L, (331.27±64.18)ng/L]( t=14.683, 19.108, P<0.001, <0.001) and the control group[(477.96±46.61)ng/L, (241.86±39.07)ng/L]( t=20.534, 30.813, P<0.001, <0.001), while Th1/Th2 level(1.65±0.37) in the acute period group was significantly lower than that in the recovery period group(1.97±0.42)( t=3.123, P=0.003) and the control group(2.28±0.56)( t=5.405, P<0.001). The levels of IFN-γ and IL-4 in the recovery period group were higher than those in the control group( t=5.729, 7.805, P=0.003, <0.001), while Th1/Th2 level in the recovery period group was lower than that in the control group( t=2.652, P=0.010). Conclusion:There are immune disorders of Th2 advantages in MPP children.
