Effect of Zhenju hypotensive tablet combined with nifedipine sustained release tablet on essential hypertension and its influence on vascular endothelial function, expression of CysC, Hcy and hs-CRP
10.3760/cma.j.issn.1008-6706.2020.23.018
- VernacularTitle:珍菊降压片联合硝苯地平缓释片治疗原发性高血压疗效观察及对血管内皮功能、胱抑素C、同型半胱氨酸和超敏C反应蛋白水平的影响
- Author:
Ting LI
1
;
Shanying WU
;
Fang SU
Author Information
1. 浙江省，诸暨市中医医院中药房 311800
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(23):2895-2899
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic effect of Zhenju hypotensive tablet combined with nifedipine sustained-release tablet in the treatment of essential hypertension, and its influence on the vascular endothelial function, expression of cystatin C (CysC), homocysteine (Hcy) and hypersensitive C-reactive protein (hs-CRP).Methods:From September 2018 to September 2019, 182 patients with essential hypertension were enrolled in Zhuji Hospital of Traditional Chinese Medicine.They were divided into observation group (91 cases) and control group (91 cases) according to the random digital table method.The control group was given nifedipine sustained-release tablets, while the observation group received Zhenju hypotensive tablets on the basis of the control group.The course of treatment in both two groups was 12 weeks.After treatment, the changes of blood pressure, endothelial function, CysC, Hcy and hs-CRP levels and adverse reactions were compared.Results:The total effective rate of the observation group (91.21%) was higher than that of the control group (79.12%) (χ 2=5.262, P<0.05). The SBP and DBP in the two groups were decreased after treatment for 12 weeks ( tobservation group=29.054, 26.702, tcontrol grou P=27.449, 20.145, all P<0.05). The SBP and DBP in the observation group were lower than those in the control group ( t=12.704, 8.177, all P<0.05). After treatment for 12 weeks, the plasma level of ET-1 in the two groups were lower than those before treatment, and the level of NO the two groups were higher than those before treatment ( tobservation group=27.388, 18.644, tcontrol group=9.480, 9.657, all P<0.05). The plasma level of ET-1 in the observation group was lower than that in the control group, and the level of NO in the observation group was higher than that in the control group, the differences were statistically significant( t=22.384, 9.134, all P<0.05). The levels of CysC, Hcy and hs-CRP in the two groups after treatment for 12 weeks were lower than those before treatment ( tobservation group=31.586, 23.159, 29.776, tcontrol grou P=11.641, 13.649, 16.521, all P<0.05). The levels of CysC, Hcy and hs-CRP in the observation group were lower than those in the control group ( t=17.193, 10.554, 14.671, all P<0.05). The adverse reaction in the observation group was less than those in the control group (χ 2=7.959, P<0.05). Conclusion:Zhenju hypotensive tablet combined with nifedipine sustained-release tablet has good therapeutic effect in the treatment of essential hypertension.It can improve the vascular endothelial function, reduce the expression of CysC, Hcy and hs-CRP, and has fewer adverse reactions.
