Effect of escitalopram oxalate combined with low dose olanzapine on negative emotion and neurological function in depressive patients
10.3760/cma.j.issn.1008-6706.2020.22.016
- VernacularTitle:草酸艾司西酞普兰联合小剂量奥氮平对抑郁症患者负性情绪及神经功能的影响
- Author:
Jianhai HUANG
1
;
Mengpu WANG
;
Ping YU
Author Information
1. 温州医科大学附属康宁医院精神科 325000
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(22):2758-2762
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of escitalopram oxalate combined with low dose olanzapine on negative emotion and neurological function in patients with depression.Methods:From July 2018 to January 2019, 120 depressive patients who admitted to the Affiliated Kangning Hospital of Wengzhou Medical University were prospectively selected and divided into two groups according to random number table method, with 60 cases in each group.The observation group was treated with escitalopram oxalate combined with low dose olanzapine, while the control group was treated with escitalopram oxalate.The clinical efficacy, related scale scores, neurological function indicators and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was 85.0%(51/60) at 2 months after treatment, which was significantly higher than 63.3%(38/60) in the control group(χ 2=7.350, P=0.007). At 2 months after treatment, the scores of Mini mental state examination, Hamilton anxiety scale and Hamilton depression scale in the observation group were (12.58±1.34)points, (33.27±4.32)points, (36.72±4.93)points, respectively, which were lower than those in the control group [(16.93±1.46)points, (41.82±3.95)points, (47.61±5.09)points] ( t=17.003, 11.304, 11.904, all P<0.001). At 2 months after treatment, the level of brain-derived neurotrophic factor in the observation group was (33.26±3.52)μg/L, which was higher than that in the control group [(28.27±3.43)μg/L]( t=7.864, P<0.001). The S100B protein, myelin basic protein, neuron-specific enolase levels in the observation group were (0.76±0.09)μg/L, (5.16±0.97)μg/L, (4.63±1.21)μg/L, respectively, which were lower than those in the control group [(1.31±0.12)μg/L, (7.36±0.83)μg/L, (7.72±1.69)μg/L]( t=13.348, 11.505, 28.402, all P<0.001). The incidences of adverse reactions in the control group and the observation group were 10.0%(6/60) and 13.3%(8/60), respectively, there was no statistically significant difference between the two groups(χ 2=0.323, P=0.570). Conclusion:Escitalopram oxalate combined with low dose olanzapine is effective in the treatment of depression.It can effectively improve the negative mood and neurological function of patients.
