Clincal value of NSE in the diagnosis of neuroblastoma in children
10.3760/cma.j.issn.1008-6706.2020.22.014
- VernacularTitle:血清神经元特异性烯醇化酶在神经母细胞瘤患儿诊断中的应用价值
- Author:
Jian LI
1
;
Xiaobing SUN
;
Jinyu DAI
;
Fengling TONG
Author Information
1. 山西省儿童医院普外科，太原 030013
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(22):2749-2752
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the application value of serum neuron-specific enolase(NSE) in the diagnosis of neuroblastoma in children.Methods:The clinical data of 98 children with neuroblastoma admitted to Children's Hospital of Shanxi Province from January 2010 to January 2018 were retrospectively analyzed(study group), and 40 healthy children with physical examination during the same period were selected as control group.The serum NSE levels were detected in the study group at the time of diagnosis and after treatment, and in the control group at the time of physical examination, to evaluate the effectiveness of NSE level changes in the diagnosis of neuroblastoma in children.Results:The serum NSE level in the study group[(98.61±10.42)μg/L] was higher than that in the control group[(15.31±1.16)μg/L]( t=50.325, P<0.05). At the time of diagnosis, the serum NSE levels of stage II, III and IV were (31.56±12.82)μg/L, (78.65±20.1)μg/L and (127.45±32.48)μg/L, respectively, showed an increasing trend( F=111.556, P=0.000). The serum NSE level of the study group after treatment[(62.48±7.46)μg/L] was lower than that before treatment[(98.61±10.42)μg/L]( t=27.910, P<0.05), and the serum NSE levels of children at different stages were lower than those before treatment(all P<0.05). The receiver operating characteristic (ROC) curve was drawn with serum NSE as the variable, showed the area under the curve of 0.815, the Yoden index of 0.534, the sensitivity of 71.43%, and the specificity of 90.82%. Conclusion:Serum NSE detection plays an important role in the diagnosis of neuroblastoma in children, and is conducive to the judgment of the severity of the disease, the treatment effect, with high diagnostic performance.It is worthy of clinical promotion.
