Study on the correlation between OPRM1 A118G gene polymorphism(rs1799971) and dosage of opioid analgesics in patients after lumbar decompression
10.3760/cma.j.issn.1008-6706.2020.21.009
- VernacularTitle:OPRM1 A118G基因多态性(rs1799971)与腰椎减压术后患者阿片类镇痛药物用量的相关性研究
- Author:
Guiping XU
1
;
Nan CHEN
;
Simayi ALIMUJIANG·
;
Huihong YANG
;
Xueping MA
Author Information
1. 新疆维吾尔自治区人民医院麻醉科，乌鲁木齐 830000
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(21):2600-2604
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation between OPRM1 A118G gene polymorphism (rs1799971) and the dosage of opioid analgesics in patients after lumbar decompression.Methods:From July 2017 to September 2018, 147 patients undergoing selective posterior lumbar decompression under general anesthesia in the People's Hospital of Xinjiang Uygur Autonomous Region were treated with sufentanil intravenous controlled analgesia(PCIA). The gene polymorphism was detected by PCR.The VAS, Ramasy sedation score, total dosage of sufentanil and adverse reactions of sufentanil in 48 h after operation were observed.Results:The genotype frequencies of AA, GA and GG were 30.6%, 55.5% and 13.9%, respectively, the difference was statistically significant(χ 2=6.324, P=0.423), and G and A allele frequencies were 41.7%, 58.3%, respectively, the difference was statistically significant(χ 2=5.559, P=0.184). There were no statistically significant differences in SpO 2, Ramasay sedation score and VAS score among the groups after operation(all P>0.05). The total dosage of sufentanil in OPRM1 mutant GG[(151.0±23.4)μg] and GA[(132.0±19.1)μg] was higher than that in AA[(123.0±16.2)μg] within 48 h of PCIA, the differences were statistically significant( t=5.206, 2.817, all P<0.05). Conclusion:The OPRM1 A118G gene polymorphism(rs1799971) is correlated with the dosage of opioid analgesics after lumbar decompression.
