Application of QF-PCR in amniotic fluid rapid prenatal diagnosis
10.3760/cma.j.issn.1008-6706.2020.20.002
- VernacularTitle:荧光定量聚合酶链式反应在羊水快速产前诊断中的应用
- Author:
Qian LI
1
;
Canming CHEN
;
Mingyan LIU
;
Shaolu YU
;
Guijiang XU
Author Information
1. 扬州大学医学院附属医院 扬州市妇幼保健院医学遗传中心 225002
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(20):2437-2439
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the clinical value of quantitative fluorescent polymerase chain reaction(QF-PCR) in rapid prenatal diagnosis.Methods:From May 2018 to May 2019, 1 190 amniotic fluid samples were detected by QF-PCR to check out aneuploidies of 13, 18, 21, X and Y, then the results were compared with those of traditional karyotype analysis.Results:The 33 abnormities including 20 cases with trisomy 21, 4 cases with trisomy 18 and 9 abnormities of sex chromosomes were checked out in 1190 amniotic fluid samples by rapid diagnosis.Conclusion:As a common rapid diagnostic method, QF-PCR has advantages of rapid and accurate, but still cannot completely replace the conventional karyotype analysis.
