Therapeutic effect of Kangfuxin solution combined with cydiodine in the treatment of patients with recurrent oral ulcer and its influence on T lymphocyte subsets and expression of IL-2 and IL-6
10.3760/cma.j.issn.1008-6706.2020.20.023
- VernacularTitle:康复新液联合西地碘治疗复发性口腔溃疡疗效观察及对T淋巴细胞亚群、白细胞介素2和白细胞介素6表达的影响
- Author:
Jiangwei YAO
1
Author Information
1. 浙江省，桐乡市第一人民医院口腔科 314500
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(20):2534-2538
- CountryChina
- Language:Chinese
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Abstract:
Objective:To investigate the therapeutic effect of Kangfuxin solution combined with cydiodine on recurrent oral ulcer, and its influence on T lymphocyte subsets and serum interleukin-2(IL-2) and interleukin-6(IL-6).Methods:From December 2017 to December 2019, 296 patients with recurrent aphthous ulcer admitted to the First People's Hospital of Tongxiang were randomly divided into observation group(148 cases) and control group(148 cases) according to the random digital table method.The patients in the control group were treated with cydiodine, while the patients in the observation group were treated with Kangfuxin solution on the basis of the control group.The course of treatment in both two groups was 4 weeks.The changes of T lymphocyte subsets, IL-2 and IL-6 levels, ulcer pain and ulcer diameter before and after treatment were compared.Results:The total effective rate of the observation group(93.92%) was higher than that of the control group(84.46%)(χ 2=6.867, P<0.05). After treatment, CD 4+ [(39.84±1.76)%] and CD 4+/CD 8+(1.82±0.15) in the observation group were higher than those in the control group [(36.51±1.98)% and (1.47±0.12)], while CD 8+ [(22.16±1.46)%] was lower than that in the control group [(24.87±1.37)%], the differences were statistically significant between the two groups( t=15.292, 16.467, 22.166, all P<0.05). After treatment, the serum level of IL-2 [(189.84±17.86)ng/L] in the observation group was higher than that in the control group[(147.82±14.27)ng/L], while the serum level of IL-6[(37.48±6.57)ng/L] was lower than that in the control group [(59.76±12.14)ng/L], the differences were statistically significant between the two groups( t=22.361, 19.636, all P<0.05). The VAS score[(1.36±0.29)points] and ulcer diameter[(1.54±0.38)mm] in the observation group were lower than those in the control group[(2.57±0.41)points, (2.26±0.43)mm]( t=29.312, 15.264, all P<0.05). Conclusion:Kangfuxin solution combined with cydiodine has obvious curative effect in the treatment of recurrent oral ulcer, which can improve the immune function and reduce the reaction, relieve the pain of ulcer and reduce the diameter of ulcer.
