Effect of anti-osteoporosis drugs on hand function of hemiplegic patients after stroke
10.3760/cma.j.issn.1008-6706.2020.20.017
- VernacularTitle:抗骨质疏松药物干预对脑卒中后偏瘫患者手功能的影响
- Author:
Xuelian WANG
1
;
Zhifang MAO
Author Information
1. 浙江省，衢州市第三医院老年康复科 324000
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(20):2505-2510
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of prophylactic use of anti-osteoporosis drugs on hand function in hemiplegic patients after stroke.Methods:From January 2018 to October 2019, 66 patients with hemiplegia after stroke admitted to the Third Hospital of Quzhou were selected and randomly divided into observation group and control group according to the random digital table method, with 33 cases in each group.The control group was given routine rehabilitation treatment, the observation group was given calcium carbonate D3 combined with calcitriol preventive anti-osteoporosis treatment.The two groups were treated for 12 weeks.Before and after treatment, the Brunnstrom stage score, Fugl Meyer(FMA) score, Wolf exercise score, modified Barthel index score, bone mineral density(BMD) and bone markers were compared between the two groups.Results:After treatment for 4, 8, 12 weeks, the Brunnstrom stage scores of the observation group were (2.97±0.90)points, (3.89±1.04)points, (4.68±1.04)points, respectively, which were higher than those of the control group[(2.46±0.89)points, (3.13±0.97)points, (4.09±0.97)points]( t=2.315, 3.070, 2.383, all P<0.05)and the FMA scores of the observation group were (34.28±5.17)points, (49.12±6.24)points, (55.73±6.74)points, respectively, which were higher than those of the control group [(30.07±5.05)points, (44.78±6.03)points, (50.10±6.71)points] ( t=3.346, 2.873, 3.401, all P<0.05), and the Wolf exercise scores of the observation groupwere (1.83±0.45)points, (2.91±0.64)points, (3.96±0.91)points, which were higher than those of the control group [(1.49±0.49)points, (2.28±0.57)points, (3.42±0.83)points] ( t=2.936, 4.223, 2.519, all P<0.05), and the Barthel index scores of the observation group were (59.12±5.73)points, (71.34±6.03)points, (78.98±6.89)points, respectively, which were higher than those of the control group [(55.14±5.62)points, (65.23±6.19)points, (71.54±6.80)points] ( t=2.849, 4.062, 4.415, all P<0.05). After 4, 8 and 12 weeks of treatment, BMD level of lumbar spine and hip in the observation group were higher than those in the control group, and the differences were statistically significant(all P<0.05). After 4, 8 and 12 weeks of treatment, the total amino terminal propeptides of type I collagen in the observation group were (76.02±7.26)μg/L, (58.34±6.45)μg/L, (49.12±5.12)μg/L, respectively, which were lower than those in the control group[(79.98±7.13)μg/L, (64.48±6.71)μg/L, (54.29±5.15)μg/L]( t=2.236, 3.790, 4.090, all P<0.05), and the serum osteocalcin levels in the observation group were (3.41±0.53)ng/L, (4.75±0.49)ng/L, (6.09±0.72)ng/L, respectively, which were higher than those of the control group [(3.02±0.48)ng/L, (4.16±0.47)ng/L, (5.41±0.67)ng/L]( t=3.133, 4.992, 3.972, all P<0.05)and the 25 dihydroxyvitamin D3 levels in the observation group were (34.87±5.41)ng/L, (48.71±5.67)ng/L, (72.67±6.95)ng/L, respectively, which were higher than those of the control group [(30.22±5.30)ng/L, (42.35±5.12)ng/L, (64.62± 6.14)ng/L]( t=3.527, 4.782, 4.987, all P<0.05). Conclusion:The preventive use of anti-osteoporosis drugs in patients with hemiplegia after stroke has significant effect, which can improve the function of hands and upper limbs, improve the quality of life of patients, improve the bone density and improve the bone metabolism index of patients.
