Study on the correlation between carotid atherosclerosis and osteocalcin in patients with type 2 diabetes
10.3760/cma.j.issn.1008-6706.2020.17.017
- VernacularTitle:2型糖尿病患者颈动脉粥样硬化与骨钙素的相关性研究
- Author:
Dihua HUANG
1
;
Dajun LOU
;
Qiaoying YOU
;
Lihong YU
;
Xiaojie PAN
;
Xuwei SI
Author Information
1. 绍兴市人民医院 浙江大学绍兴医院内分泌代谢科 312000
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(17):2126-2129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between carotid atherosclerosis (CAS) and bone metabolism marker osteocalcin (OC) in patients with type 2 diabetes (T2DM).Methods:A total of 100 patients with T2DM admitted to Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University) from January 2018 to August 2018 were selected as study subjects, and the carotid intima-media thickness (IMT) was detected.The patients were divided into CAS group and normal carotid IMT group (NC group), with 50 cases in each group.The levels of OC, fasting plasma glucose(FPG), fasting insulin(FINS), glycosylated hemoglobin(HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein(HDL-C), low density lipoprotein (LDL-C), insulin resistance index (HOMA-IR) were compared between the two groups.Results:The OC level of the CAS group[(11.86±4.46)ng/mL] was significantly lower than that of the NC group[(23.94±4.52)ng/mL] ( t=-9.640, P=0.001). The LDL-C level of the CAS group[(2.89±0.82)mmol/L] was significantly higher than that of the NC group[(2.55±1.16)mmol/L]( t=2.03, P=0.049). Pearson correlation analysis showed that IMT was positively correlated with age, LDL-C, HbA1c ( r=0.285, 0.190, 0.173; P=0.000, 0.020, 0.035), and negatively correlated with OC ( r=-0.603, P=0.000). Conclusion:CAS in patients with T2DM is closely related to OC, and the reduction of OC levels may be a risk factor for CAS in T2DM patients.
