Therapeutic effect of Weichangning granule combined with compound Lactobacillus acidophilus tablet in the treatment of diarrhea type irritable bowel syndrome and its effect on inflammatory factors, gastrointestinal hormones and intestinal mucosal barrier
10.3760/cma.j.issn.1008-6706.2020.16.008
- VernacularTitle:胃肠宁颗粒联合复方嗜酸乳杆菌片治疗腹泻型肠易激综合征的疗效及其对患者炎性因子、胃肠激素和肠黏膜屏障的影响
- Author:
Jianhua JIANG
1
;
Jing JIANG
;
Yonghang FENG
;
Chuan GAO
Author Information
1. 杭州市富阳区第一人民医院内镜中心 311400
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(16):1952-1956
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic effect of Weichangning granule combined with compound Lactobacillus acidophilus tablet on diarrhea type irritable bowel syndrome and its effect on inflammatory factors, gastrointestinal hormones and intestinal mucosal barrier.Methods:From January 2017 to December 2019, 80 patients with diarrhea type irritable bowel syndrome admitted in the First People's Hospital of Fuyang District were selected, and they were divided into observation group and control group according to the random digital table method, with 40 cases in each group.The control group was treated with relapsed Lactobacillus acidophilus tablets, and the observation group was treated with Weichangning granules on the basis of the control group.The course of treatment in both two groups was 2 weeks.The changes of inflammatory factors, gastrointestinal hormones and intestinal mucosal barrier were compared before and after treatment.Results:The total effective rate of the observation group[92.50%(37/40)] was higher than that of the control group[70.00%(28/40)], the difference was significant (χ 2=6.646, P<0.05). The levels of TNF-α[(36.15±10.12)ng/L], IL-1β[(0.43±0.08)μg/L] and IL-6[(12.18±3.06)ng/L] in the observation group were lower than those in the control group[(54.36±15.73)ng/L, (0.79±0.12)μg/L and (18.53±2.19)ng/L]( t=6.157, 15.787, 10.673, all P<0.05). The serum levels of SS[(28.91±11.02)μg/L] and VIP[(185.46±17.34)ng/L] in the observation group were lower than those in the control group[(45.63±12.54)μg/L and (235.12±18.29)ng/L]( t=6.334, 12.462, all P<0.05). The levels of DAO[(1.05±0.19)U/L], endotoxin[(0.62±0.19)U/L] and D-lactate[(38.97±6.39)mg/L] in the observation group were lower than those in the control group[(1.53±0.28)U/L, (1.16±0.23)U/L and (49.81±4.25)mg/L]( t=8.972, 11.448, 8.934, all P<0.05). Conclusion:Weichangning granule combined with compound Lactobacillus acidophilus tablet has obviously curative effect on diarrhea type irritable bowel syndrome, which can reduce inflammatory reaction, improve gastrointestinal hormone and intestinal mucosal barrier function.
