Effect of MPST in the treatment of hypertensive intracerebral hemorrhage and its influence on the expression of MMP-9, IL-8 and NSE
10.3760/cma.j.issn.1008-6706.2020.16.023
- VernacularTitle:微创颅内血肿清除术治疗高血压脑出血的效果及对血清基质金属蛋白酶9、白细胞介素8、神经元特异性烯醇化酶表达的影响
- Author:
Kehui LUO
1
;
Meibiao ZHANG
;
Fan SUN
;
He ZHENG
;
Xixiong GUO
;
Xiaolong XIA
Author Information
1. 浙江省，兰溪市人民医院神经外科 321100
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(16):2017-2021
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of microinvasive craniopuncture scavenging technique(MPST) in the treatment of hypertensive intracerebral hemorrhage, and its influence on the expression of serum matrix metalloproteinase-9 (MMP-9), interleukin-8 (IL-8) and neuron specific enolase (NSE).Methods:From January 2017 to December 2018, 60 cases with hypertensive cerebral hemorrhage in Lanxi People's Hospital of Zhejiang province were divided into observation group (30 cases) and control group (30 cases) according to the digital table method.The control group was treated with conventional therapy, while the observation group was treated with MPST on the basis of the control group.The therapeutic effects of the two groups were compared, and the changes of Barthel index (BI) score, NIHSS score, perihematoma edema, MMP-9, IL-8 and NSE levels were compared.Results:The total effective rate in the observation group(93.33%) was higher than that in the control group (70.00%) (χ 2=5.455, P<0.05). The BI score[(60.19±5.87)points] of the observation group was higher than that of the control group[(49.83±4.56)points], while the NIHSS score[(7.93±1.42)points] was lower than that of the control group[(12.87±2.10)points]( t=7.634, 10.673, all P<0.05). The amount of edema around hematoma in the observation group [(6.20±1.27)mL] was lower than that in the control group [(9.83±1.76)mL] ( t=9.161, P<0.05). The levels of MMP-9 [(103.24±17.38)μg/L], IL-8 [(137.28±25.46)μg/L] and NSE [(8.98±2.16)μg/L] in the observation group were lower than those in the control group [(168.39±15.42)μg/L, (195.31±39.71)μg/L and (13.13±2.63)μg/L] ( t=15.358, 6.738 and 6.679, all P<0.05). Conclusion:MPST is effective in the treatment of hypertensive intracerebral hemorrhage, and it can reduce the serum levels of MMP-9, IL-8 and NSE.
