Effects of metoprolol tartrate combined with atorvastatin calcium on lipid metabolism, vascular endothelial function and inflammatory factors in patients with essential hypertension
10.3760/cma.j.issn.1008-6706.2020.15.004
- VernacularTitle:美托洛尔联合阿托伐他汀钙对原发性高血压患者脂代谢、血管内皮功能和炎性因子的影响
- Author:
Feixiang LI
1
;
Jiren PENG
;
Jiaojiao MA
Author Information
1. 浙江省，东阳市人民医院心血管内科 322100
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(15):1808-1812
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of metoprolol tartrate combined with atorvastatin calcium on lipid metabolism, vascular endothelial function and inflammatory factors in patients with essential hypertension.Methods:From January 2015 to December 2018, 80 patients with essential hypertension admitted to the People's Hospital of Dongyang were divided into observation group (40 cases) and control group (40 cases) according to the random digital table method.On the basis of routine treatment, the control group was treated with atorvastatin calcium, while the observation group was treated with atorvastatin calcium and metoprolol.The course of treatment in both two groups was 6 months.The changes of systolic and diastolic blood pressure, lipid metabolism, endothelial function and inflammatory factors were compared before and after treatment.Results:The total effective rate of the observation group (92.50%, 37/40) was higher than that of the control group (70.00%, 28/40) (χ 2=6.646, P<0.05). The systolic blood pressure [(123.15±7.89) mmHg] and diastolic blood pressure [(75.52±3.89)mmHg] in the observation group were lower than those in the control group [(134.29±10.31)mmHg and (82.31±4.04)mmHg] ( t=5.427, 7.657, all P<0.05). The level of serum NO [(69.74±5.46)nmol/L] in the observation group was higher than that in the control group [(57.87±3.67)nmol/L], while ET-1 [(56.48±5.49)mg/L] in the observation group was lower than that in the control group [(73.24±7.18)mg/L], the differences were statistically significant( t=11.411, 11.728, all P<0.05). The serum levels of CRP [(1.18±0.23)mg/L], TNF-α [(0.63±0.18)μg/L] and IL-6 [(84.35±17.28)ng/L] in the observation group were lower than those in the control group [(1.64±0.45)mg/L, (1.23±0.26)μg/L and (128.43±19.86)ng/L] ( t=5.757, 12.000, 10.590, all P<0.05). Conclusion:Metoprolol tartrate combined with atorvastatin calcium is effective in the treatment of essential hypertension, and can improve lipid metabolism, vascular endothelial function, and reduce inflammation.
