Effect of combination of magnesium aluminum carbonate and lansoprazole sodium in the treatment of gastric ulcer
10.3760/cma.j.issn.1008-6706.2020.13.009
- VernacularTitle:铝碳酸镁联合兰索拉唑治疗胃溃疡效果观察
- Author:
Liujun CHEN
1
Author Information
1. 杭州市大江东医院消化内科 311225
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(13):1573-1576
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of combination of aluminum magnesium carbonate and lansoprazole sodium in the treatment of gastric ulcer.Methods:From October 2017 to October 2018, 100 patients with gastric ulcer in Hangzhou Dajiangdong Hospital were randomly divided into control group and observation group by random number table method, with 50 cases in each group.The control group was treated with routine triple therapy, and the observation group was treated with aluminum magnesium carbonate combined with lansoprazole sodium capsule.The course of treatment in both two groups was eight weeks.The curative effect of the two groups was observed.Results:The total effective rate of the observation group was 96.0%(48/50), which was higher than that of the control group [70.0%(35/50)], the difference was statistically significant(χ 2=12.428, P<0.01). After treatment, the motilin, gastrin, percentages of collagen fiber area and neutral mucus area in the observation group were (255.22±36.29)ng/L, (142.19±9.86)μg/L, (46.29±5.27)%, (55.29±6.82)%, respectively, which were better than those in the control group [(281.73±30.84)ng/L, (114.58±8.35)μg/L, (35.69±4.38)%, (36.75±5.23)%], the differences were statistically significant( t=36.582, 31.125, 12.785, 21.745, all P<0.05). The scores of abdominal pain, belching, acid regurgitation and abdominal distension in the observation group were (1.46±0.52)points, (0.35±0.05)points, (0.49±0.13)points and (1.38±0.23)points, respectively, which were lower than those in the control group [(2.58±0.41)points, (1.46±0.71)points, (1.28±0.54)points and (2.65±0.48)points] ( t=1.836, 1.485, 1.023, 1.258, all P<0.05). The incidence of adverse reactions in the observation group[4.0%(2/50)] was lower than that in the control group [30.0%(15/50)](χ 2=14.258, P<0.01). Conclusion:The combination of magnesium aluminum carbonate and lansoprazole sodium has good clinical effect on gastric ulcer, which is superior to the conventional triple therapy.
