Effects of micropulse laser photocoagulation under threshold on serum malondialdehyde and chemokine levels in patients with proliferative diabetic retinopathy
10.3760/cma.j.issn.1008-6706.2020.13.014
- VernacularTitle:阈值下微脉冲激光光凝对增殖性糖尿病视网膜病变患者血清丙二醛及趋化素水平的影响
- Author:
Linping LIU
1
;
Bole WU
;
Jun LI
;
Lina ZHANG
;
Lisha NI
;
Zong WANG
Author Information
1. 浙江省，丽水市人民医院眼科 323000
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(13):1596-1600
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of micropulse laser photocoagulation under threshold on serum malondialdehyde(MDA) and chemokine levels in patients with proliferative diabetic retinopathy(PDR).Methods:From October 2014 to February 2016, 102 patients with PDR who were treated in Lishui People's Hospital were selected and divided into two groups by random number table method, with 51 cases in each group.The patients in the control group were treated with traditional grating laser, and the patients in the observation group were treated with micropulse laser photocoagulation under threshold.The levels of MDA and chemokine were compared before and after treatment, and the changes of vision and clinical efficacy were observed.Results:The total effective rate of the observation group was 90.20%(46/51), which was higher than that of the control group [76.47%(39/51)](χ 2=19.585, P<0.01). Before treatment, there were no statistically significant differences in serum MDA, chemokine and visual acuity between the two groups(all P>0.05). After treatment, the serum MDA and chemokines in the observation group were (8.57±2.48)μmol/L and (1.58±0.51)ng/L, respectively, which were lower than those in the control group [(10.92±3.16)μmol/L and (2.83±0.92)ng/L]( t=4.178, 8.486, all P<0.05), which in both two groups after treatment were lower than those before treatment(all P<0.05). The visual acuity of the observation group was (0.66±0.19), which was higher than that of the control group(0.43±0.13)( t=7.135, P<0.05). Conclusion:Micropulse laser photocoagulation under threshold can effectively alleviate oxidative stress and reduce serum MDA and chemokine levels in patients with PDR.
