Correlation analysis between adiponectin and HMGB1 in patients with acute cerebral infarction complicated by myocardial infarction
10.3760/cma.j.issn.1008-6706.2020.12.014
- VernacularTitle:急性脑梗死患者脂联素、高迁移率族蛋白1以及胰岛素抵抗水平与合并心肌梗死的相关性分析
- Author:
Huijie ZHOU
1
;
Yuanying YU
;
Xiaolei WANG
;
Zuguang LIU
;
Lihua FENG
Author Information
1. 山东省，海阳市人民医院神经内科 265100
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(12):1466-1471
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the level of serum adiponectin (APN), high mobility group box 1 (HMGB1) and insulin resistance in patients with acute cerebral infarction complicated by myocardial infarction, and try to investigate the correlation between them.Methods:From January 2016 to June 2019, 448 patients who diagnosed as acute cerebral infarction in Haiyang People's Hospital were selected.The patients were divided into myocardial infarction(MI) group (36 cases) and non-MI group (412 cases) based on whether they complicated with MI.And 50 healthy people were selected as healthy control group.Fasting venous blood was collected from all subjects, and the adiponectin, HMGB1, coagulation indicators, inflammatory indicators, myocardial infarction markers and insulin resistance were measured.Results:The markers of myocardial infarction (CK-MB, cTnⅠ, Mb), coagulation indicators (APTT, PT, AT-Ⅲ, ACT), inflammatory levels (HMGB1, APN, CRP, IL-6)and insulin resistance related indicators (FPG, FINS, HOMA-IR, ISI)in patients with MI were different from patients with non-MI [CK-MB: (25.33±4.61)μg/L vs.(21.85±4.73)μg/L, t=6.028, P<0.001; cTnⅠ: (7.96±0.98)μg/L vs.(4.89±1.05)μg/L, t=24.135, P<0.001; Mb: (91.07±15.21)g/L vs.(147.53±16.04)g/L, t=28.981, P<0.001; APTT: (34.02±6.12)s vs.(37.21±6.31)s, t=4.144, P=0.005; PT: (14.32±1.21)s vs.(12.94±1.37)s, t=8.390, P<0.001; AT-Ⅲ: (144.62±18.35)s vs.(167.53±20.04)s, t=9.382, P<0.001; ACT: (135.84±15.21)s vs.(145.06±16.02)s, t=4.711, P<0.001; HMGB1: (25.61±3.84)μg/mL vs.(19.27±4.21)μg/mL, t=12.456, P<0.001; APN: (6.03±0.78)mg/L vs.(9.16±0.97)mg/L, t=26.995, P<0.001; CRP: (46.12±2.87)mg/L vs.(39.36±3.21)mg/L, t=17.608, P<0.001; IL-6: (8.76±1.42)mg/L vs.(5.04±1.22)mg/L, t=25.238, P<0.001; FPG: (6.27±0.98)mmol/L vs.(5.62±1.05)mmol/L, t=5.106, P<0.001; FINS: (24.07±4.25)mIU/L vs.(15.84±4.46)mIU/L, t=15.235, P<0.001; HOMA-IR: (6.68±0.68)vs.(3.96±0.84), t=27.217, P<0.001; ISI: (-5.03±0.84)vs.(-4.57±0.97), t=3.963, P<0.001] and the healthy controls [CK-MB: (25.33±4.61)μg/L vs.(20.04±4.52)μg/L, t=7.280, P<0.001; cTnⅠ: (7.96±0.98)μg/L vs.(4.04±0.95)μg/L, t=24.482, P<0.001; Mb: (91.07±15.21)g/L vs.(194.23±14.79)g/L, t=42.067, P<0.001; APTT: (34.02±6.12)s vs.(40.89±6.02)s, t=7.090, P<0.001; PT: (14.32±1.21)s vs.(10.94±1.15)s, t=16.326, P<0.001; AT-Ⅲ: (144.62±18.35)s vs.(225.31±19.64)s, t=26.249, P<0.001; ACT: (135.84±15.21)s vs.(161.32±15.77)s, t=10.342, P<0.001; HMGB1: (25.61±3.84)μg/mL vs.(6.72±3.78)μg/mL, t=29.484, P<0.001; APN: (6.03±0.78)mg/L vs.(12.54±0.82)mg/L, t=44.604, P<0.001; CRP: (46.12±2.87)mg/L vs.(7.64±2.52)mg/L, t=79.626, P<0.001; IL-6: (8.76±1.42)mg/L vs.(2.22±1.29)mg/L, t=35.249, P<0.001; FPG: (6.27±0.98)mmol/L vs.(5.15±0.96)mmol/L, t=6.989, P<0.001; FINS: (24.07±4.25)mIU/L vs.(10.64±3.96)mIU/L, t=19.751, P<0.001; HOMA-IR: (6.68±0.68)vs.(2.44±0.66), t=33.705, P<0.001; ISI: (-5.03±0.84)vs.(-3.94±0.79), t=7.460, P<0.001]. The incidence of acute cerebral infarction complicated with myocardial infarction was negatively correlated with APN and AT-Ⅲ(APN: r=-0.405, P=0.001; AT-Ⅲ: r=-0.554, P<0.001), and positively correlated with HMGB1 and HOMA-IR(HMGB1: r=0.624, P=0.005; HOMA-IR: r=0.667, P<0.001). Conclusion:There is a significant negative correlation between the occurrence of acute cerebral infarction complicated with MI and the level of APN, and positive correlations between HMGB1 and insulin resistance.
