Effect of montelukast sodium on conventional treatment of children with bronchial asthma
10.3760/cma.j.issn.1008-6706.2020.11.012
- VernacularTitle:孟鲁司特钠对支气管哮喘患儿常规治疗的疗效影响
- Author:
Lirong QIAN
1
Author Information
1. 杭州市大江东医院儿科 310000
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(11):1331-1334
- CountryChina
- Language:Chinese
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Abstract:
Objective:To explore the effect of montelukast sodium on the treatment of children with bronchial asthma.Methods:From January 2018 to October 2019, 96 children with bronchial asthma treated in Hangzhou Dajiangdong Hospital were randomly divided into control group and observation group according to random double blind method, with 48 cases in each group.The control group was treated with glucocorticoids and anti-infection, conventional treatment such as phlegm and expectoration, and the observation group was treated with montelukast sodium on the basis of conventional treatment.The inflammatory factors, pulmonary function indicators and clinical symptoms recovery time were compared between the two groups before and after treatment.Results:The cough, wheezing and lung murmur disappearing time in the observation group were (3.84±1.87)d, (2.68±0.75)d, (4.35±1.05)d, respectively, which were shorter than those in the control group[(5.78±2.01)d, (3.97±1.01)d, (7.16±1.34)d], the differences were statistically significant( t=4.740, 6.879, 11.073, all P<0.05). The expressions of interleukin-8, tumor necrosis factor-ɑ and interleukin-6 in the observation group were lower than those in the control group(all P<0.05). The forced expiratory volume in the first second, peak expiratory velocity and forced expiratory volume in the first second/forced vital capacity in the observation group were higher than those in the control group, the differences were statistically significant( t=5.531, 4.155, 8.090, all P<0.05). Conclusion:Montelukast sodium can improve lung function and reduce serum inflammatory response in children with bronchial asthma, which is of great clinical significance.
