Expression and clinical significance of microRNA-126, microRNA-155, Klotho protein and TGF-β1 protein in peripheral blood of patients with essential hypertension
10.3760/cma.j.issn.1008-6706.2020.07.007
- VernacularTitle:原发性高血压患者外周血微小RNA-126、微小RNA-155、Klotho蛋白、转化生长因子β1蛋白表达及临床意义
- Author:
Junchong CHEN
1
Author Information
1. 浙江省，丽水市中心医院心血管内科 323020
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(7):795-798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of microRNA-126, microRNA-155, Klotho protein and transforming growth factor-β1 (TGF-β1) in peripheral blood of patients with essential hypertension.Methods:From December 2015 to December 2018, 80 patients with essential hypertension admitted to Lishui Central Hospital were selected in the study, and 80 healthy people from Lishui Central Hospital from December 2015 to December 2018 were selected as the control group.The expressions of microRNA-126 and microRNA-155 were detected by RT-PCR, and the expressions of Klotho and TGF-β1 were detected by ELISA.The changes of systolic and diastolic blood pressure, the expressions of microRNA-126 and microRNA-155 in peripheral blood, Klotho protein and TGF-β1 protein were compared between the two groups.Results:The expression of microRNA-126 (0.23±0.07) and microRNA-155 (0.84±0.14) in peripheral blood of the hypertension group was lower than that of the control group [(1.16±0.24) and (1.37±0.21)] ( t=33.273, 18.782, all P<0.05). The serum levels of Klotho protein in the hypertension group[(123.42±9.47)ng/L] was lower than that in the control group [(143.56±14.68)ng/L], while the serum level of TGF-β1 protein the hypertension group[(561.32±58.39)ng/L] was higher than that in the control group [(408.97±25.13)ng/L] ( t=10.312, 21.436, all P<0.05). Conclusion:The expression of microRNA-126 and microRNA-155 in peripheral blood of patients with essential hypertension is down-regulated, and the expression of Klotho protein and TGF-β1 protein is up-regulated, which has certain guiding significance for clinical diagnosis and treatment.
