Diagnostic value of combined detection of four-item urinary protein for early hypertensive kidney injury
10.3760/cma.j.issn.1008-6706.2020.07.004
- VernacularTitle:尿蛋白四项联合检测对高血压肾早期损伤的诊断价值
- Author:
Yajun MA
1
;
Peng CHENG
;
Fudi CHU
Author Information
1. 山东省，滕州市中心人民医院检验科 277500
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(7):781-785
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic value of combined detection of urine α 1-microglobulin(α 1-mG), N-acetyl-β-D-glucosaminidase (NAG), retinol binding protein (RBP) and β 2-microglobulin (β 2-mG) for early hypertensive kidney injury. Methods:From June 2016 to December 2018, 116 hypertension patients with renal damage (HRD group) and 44 cases with simple hypertension(HBP group) were selected in the Central People′s Hospital of Tengzhou in this study.And 36 cases of healthy people during the same period were selected as the control group.One hundred and sixteen cases of the HRD group were divided into Ⅰ-Ⅱ group (61 cases) and Ⅲ-Ⅴ group (55 cases) according to the classification of chronic kidney disease(CKD). The concentrations of α 1-mG, NAG, RBP and β 2-mG in urine were detected in patients and healthy people respectively.SPSS 19.0 software was used to perform statistical analysis. Results:The concentrations of urine α 1-mG, NAG, RBP, β 2-mG in the HRD group were (41.77±24.21)mg/L, (22.60±13.24)U/L, (2.86±1.73)mg/L, (1.76±0.95)mg/L, respectively, which in the HBP group were (12.49±8.10)mg/L, (13.45±8.61)U/L, (0.31±0.16)mg/L, (0.38±0.38)mg/L, respectively, which in the control group were (4.37±2.52)mg/L, (6.12±3.57)U/L, (0.29±0.17)mg/L, (0.28±0.15)mg/L, respectively.The concentrations of urine α 1-mG, NAG, RBP, β 2-mG in the HRD group were significantly higher than those in the HBP group( t=4.07, 4.25, 4.09, 4.03, all P<0.05) and the control group( t=3.15, 4.94, 2.49, 2.61, all P<0.05). The urine levels of α 1-mG, NAG, RBP, β 2-mG in phase Ⅰ-Ⅱ group were (21.62±13.45)mg/L, (21.96±12.49)U/L, (0.5±0.47)mg/L, (0.93±0.62)mg/L, respectively, which in the phase Ⅲ-Ⅴ group were (64.11±60.12)mg/L, (23.32±14.11)U/L, (5.48±4.77)mg/L, (2.68±2.55)mg/L, respectively.The concentrations of urine α 1-mG, NAG, RBP and β 2-mG in Ⅰ-Ⅱ group ( t=5.08, 4.99, 2.96, 1.66, all P<0.05) and Ⅲ-Ⅴ group ( t=3.95, 4.81, 4.33, 3.74, all P<0.05) were significantly higher than those in the control group.The levels of α 1-mG, RBP and β 2-mG in group Ⅲ-Ⅴ were higher than those in group Ⅰ-Ⅱ( t=5.37, 8.11, 4.52, all P<0.05). The positive detection rates of α 1-mG, NAG, RBP, β 2-mG and combination test in phase Ⅰ-Ⅱ group were 70.5%, 77.0%, 19.7%, 60.7%, 91.8%, respectively, which in the phase Ⅲ-Ⅴ group were 81.8%, 81.8%, 69.1%, 69.1% and 96.4%, respectively.The positive rate of urine α 1-mG, NAG, RBP and β 2-mG combination test was significantly higher than that of the single detection (phase Ⅰ-Ⅱ group: χ 2=7.71, 3.99, 61.4, 14.65; phase Ⅲ-Ⅴ group: χ 2=4.58, 4.58, 12.47, 12.47; all P<0.05). Conclusion:Urine α 1-mG, NAG, RBP and β 2-mG are important biochemical indicators in patients with early hypertensive kidney injury.The combined detection of the four tests has high diagnostic value in the diagnosis of early hypertensive nephropathy.
