Comparison of clinical efficacy of dydrogesterone and progesterone in the treatment of threatened abortion
10.3760/cma.j.issn.1008-6706.2020.06.008
- VernacularTitle:地屈孕酮与黄体酮治疗先兆流产的临床疗效比较
- Author:
Shasha YING
1
;
Manzhen ZHANG
Author Information
1. 浙江省宁海县妇幼保健院西药房 315600
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(6):676-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical effect of dydrogesterone and progesterone in the treatment of threatened abortion.Methods:From March 2015 to May 2017, 50 patients with threatened abortion admitted in the Maternal and Child Health Hospital of Ninghai County were selected and randomly divided into two groups according to the digital table, with 25 cases in each group.The control group was treated with progesterone.The observation group was treated with dydrogesterone.The hormone levels, symptom disappearance time, fetal retention and adverse drug reactions were compared between the two groups.Results:One week after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (1 12.65±6.35)nmol/L, (2 137.99±371.22)pmol/L, (4 261.54±245.55)IU/L, respectively, which in the control group were (101.56±5.32)nmol/L, (1 782.12±350.71)pmol/L, (3 642.26±210.20)IU/L, respectively, the differences between the two groups were statistically significant ( t=6.694, 3.484, 9.581, all P<0.05). Three weeks after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (120.52±10.59)nmol/L, (2 240.68±409.06)pmol/L, (102.64±9.64)nmol/L, and (6 641.52±364.59)IU/L, respectively, which in the control group were (102.64±9.64)nmol/L, (1 921.76±371.07)pmol/L, (4 123.63±258.62)IU/L, respectively, the differences between the two groups were statistically significant( t=6.243, 2.887, 28.164, all P<0.05). Five weeks after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (134.15±17.16)nmol/L, (2 317.58±434.97)pmol/L, and (8 456.51±459.52)IU/L, respectively, which in the control group were (109.56±8.54)nmol/L, (2 051.38±413.39)pmol/L, (6 416.36±261.31)IU/L, respectively, the differences between the two groups were statisticallysignificant ( t=6.414, 2.218, 19.297, all P<0.05). The disappearance time of pain in the waist, abdominal pain and vaginal bleeding in the observation group was (4.15±0.25)d, (3.10±0.52)d, (4.24±0.62)d, respectively, which was shorter than that in the control group[(7.54±2.26)d, (4.31±1.10 d), (6.32±2.01)d]( t=7.455, 4.972, 4.944, all P<0.01). The success rate of fetal preservation in the observation group was 96.00%(24/25), which was higher than that in the control group[72.00%(18/25)](χ 2=5.357, P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups( P>0.05). Conclusion:The effect of dydrogesterone in the treatment of threatened abortion is better than progesterone.
