Serum vitamin D levels of atopic dermatitis in adolescents and its clinical significance
10.3760/cma.j.issn.1008-6706.2020.05.001
- VernacularTitle:青少年特应性皮炎血清维生素D水平检测及临床意义
- Author:
Shuyuan HAO
1
Author Information
1. 山西省人民医院皮肤性病科，太原 030012
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(5):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the serum level of vitamin D and severity of atopic dermatitis (AD) in adolescents.Methods:From March 2016 to February 2017, 102 adolescents with AD(AD group) and 100 healthy adolescents(control group) were selected.The distribution and serum levels of vitamin D in the two groups were compared.According to SCORing atopic dermatitis (SCORAD) score, AD patients were divided into mild group, moderate group and severe group.The levels of 25-(OH)D 3, total IgE (TIgE) and peripheral blood eosinophil cells percentage(EOS%) were detected in the three groups. Results:There was no statistically significant difference in the proportion of patients with vitamin D deficiency, insufficiency and sufficiency between the AD group and control group(χ 2=2.718, P=0.257). The serum level of 25(OH)D 3 in the AD group was lower than that in the control group[(18.43±3.73)μg/L vs.(19.47±3.27)μg/L, t=2.112, P=0.036]. The mean values of vitamin D deficiency, insufficiency and sufficiency in the AD group were (11.11±1.65)μg/L, (17.49±1.69)μg/L, (21.73±1.17)μg/L, respectively, which in the control group were (12.86±1.47)μg/L, (17.55±1.34)μg/L, (22.05±1.32)μg/L, respectively.The level of vitamin D deficiency in the AD group was significantly lower than that in the control group ( t=2.588, P=0.017), but there were no statistically significant differences in vitamin D insufficiency and sufficiency between the AD group and control group.In 102 AD patients, 40 cases were mild, 29 cases were moderate and 33 cases were severe.The levels of 25-(OH)D 3, TIgE and peripheral blood EOS% had statistically significant differences among the three groups ( F=6.315, 35.813, 31.285, all P<0.01). The 25-(OH)D 3 level of the severe group was lower than that of the mild group( t=3.64, P=0.097). However, there was no statistically significant difference between the severe and moderate groups and moderate and mild groups ( P>0.05). Regarding the TIgE level and EOS%, severe group>moderate group>mild group( t=8.318, 8.788, all P<0.01; t=4.322, 4.784, all P<0.01). The value of 25-(OH)D 3 was negatively correlated with the TIgE level( r=-302, P<0.01) and EOS%( r=-508, P<0.01) in the AD group. Conclusion:Vitamin D deficiency or insufficiency exists in adolescents with AD.Low level of vitamin D is correlated with high TIgE level and EOS%.The severity of AD is closely correlated with increased serum levels of TlgE and EOS%, as well as decreased serum levels of vitamin D.
