Meta-analysis of the relationship between arsenic exposure and pulmonary ventilation dysfunction
10.3760/cma.j.cn231583-20200528-00139
- VernacularTitle:砷暴露与肺通气功能障碍关系的Meta分析
- Author:
Fanyan ZHENG
1
;
Wenjuan WANG
;
Aihua ZHANG
Author Information
1. 贵州医科大学环境污染与疾病监控教育部重点实验室 公共卫生学院，贵阳 550025
- From:
Chinese Journal of Endemiology
2020;39(10):773-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the relationship between arsenic exposure and pulmonary ventilation dysfunction, so as to provide a basis for clarifying the mechanism of lung function injury caused by arsenic exposure and identifying at-risk populations of arsenic exposure.Methods:Pertinent studies were identified by searching PubMed, Embase, Web of Science, China Biology Medicine Disc (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP Database through March 2020. The studies that reported arsenic exposure and lung function dysfunction published at home and abroad were collected comprehensively. According to the inclusion and exclusion criteria, two reviewers independently screened and extracted the literatures. All of the Meta-analysis were performed by using Review Manager 5.3 software, the mean difference value ( MD) was used as the effect index, the fixed effect model or the random effect model were performed for comprehensive quantitative analysis according to the heterogeneity results, and subgroup analysis was conducted to explore the source of heterogeneity. Stata SE 15 software for funnel mapping and Egger's regression test were used to evaluate publication bias. Results:Totally 10 documents were included, all in English. The Meta-analysis showed that arsenic exposure could significantly reduce forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), and the MD (95% CI) was - 23.82 ( - 39.93 -- 7.72) ml and - 47.47 (- 73.97 -- 20.98) ml, respectively. The differences were statistically significant ( Ζ = 2.90, 3.51, P < 0.01). FEV1/FVC was reported in three documents, and MD (95% CI) was - 4.72 (- 13.10 - 3.67). There was no evidence of an association between arsenic exposure and FEV1/FVC ( Ζ = 1.10, P > 0.05). The results of subgroup analysis showed that there were significant differences in FEV1 and FVC among subgroups by region (χ 2 = 6.80, 30.06, P < 0.01). Conclusion:Arsenic exposure is negatively correlated with vital capacity measurement indexes FEV1 and FVC, but not with FEV1/FVC, indicating that arsenic exposure may mainly lead to restrictive pulmonary ventilation dysfunction.
