Research progress of thyroid hormone synthesis related genes and iodine metabolism and thyroid diseases
10.3760/cma.j.cn231583-20200312-00038
- VernacularTitle:甲状腺激素合成基因与碘代谢和甲状腺疾病的相关性研究进展
- Author:
Guanying NIE
1
;
Ming LI
;
Dianjun SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所 150081
- From:
Chinese Journal of Endemiology
2020;39(8):619-624
- CountryChina
- Language:Chinese
-
Abstract:
Iodine is an important raw material for thyroid hormone synthesis. Sodium iodide symporter (NIS), chloride iodine transporter (Pendrin), iodotyrosine deiodinase (IYD), thyroglobulin (TG), thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) are important genes related to thyroid hormone synthesis, all of them are involved in iodine metabolism. The dysfunction of genes related to thyroid hormone synthesis is not only related to thyroid diseases, but also related to other diseases such as breast cancer. In this paper, the function of genes related to thyroid hormone synthesis, the relationship between genes related to thyroid hormone synthesis and diseases, and how to be regulated by iodine are reviewed, in order to provide new ideas for the study of the relationship between iodine and diseases.
