Progress in arsenic-induced programmed cell death
10.3760/cma.j.cn231583-20191102-00306
- VernacularTitle:砷诱导细胞程序性死亡的研究进展
- Author:
Si DING
1
;
Mengrou XU
;
Chenghao MEI
;
Qianlei YANG
;
Jing WU
;
Yan AN
Author Information
1. 苏州大学医学部公共卫生学院卫生毒理学系 215123
- From:
Chinese Journal of Endemiology
2020;39(7):542-546
- CountryChina
- Language:Chinese
-
Abstract:
With the deepening of the research on the "two sides" of arsenic from poison to medicine, arsenic has attracted extensive attention in affecting programmed cell death (PCD) and causing damage to a variety of organs. Recent studies have showed that reactive oxygen species (ROS) produced by intracellular arsenic metabolism is closely related to PCD induction. However, the specific mechanism is still unclear. In this paper, we have reviewed the main PCD forms, such as apoptosis, autophagy and necroptosis induced by arsenic via ROS and their possible mechanisms, in order to provide basic information for further research and prevention of arsenic toxicity, which is helpful for clinical development and utilization of arsenic in the treatment of tumors and related diseases.
