Advances in research of anti-parasitic infections by berberine and its derivatives
10.3760/cma.j.cn231583-20190924-00258
- VernacularTitle:小檗碱及其衍生物抗寄生虫感染的研究进展
- Author:
Yuqing CHANG
1
;
Xu MEI
;
Yongheng HOU
;
Jianping SONG
;
Fangli LYU
Author Information
1. 广州中医药大学青蒿研究中心 510405
- From:
Chinese Journal of Endemiology
2020;39(6):457-462
- CountryChina
- Language:Chinese
-
Abstract:
Parasitic diseases still remain the world's greatest health problems and cause huge economic burden in poor areas. The drugs currently used to treat protozoiases and helminthiases have certain defects, and it is urgent to develop more effective therapeutic drugs for these diseases. Berberine is one kind of important anti-inflammatory agents originally derived from Coptis rhizoma. The derivatives of berberine are obtained by modifying the structural site of berberine. In addition to its anti-inflammatory and anti-microbial activities, berberine and its derivatives also have significant anti-parasitic activity. In this paper, we summarized recent progress in the use of berberine and its derivatives against the infections of protozoa ( Leishmania spp ., Trypanosoma spp. , Toxoplasma gondii, Plasmodium falciparum, and Eimeria tenella) and helminths ( Schistosoma mansoni, Schistosoma. japonicum, Echinococcus granulosus, and Toxocara canis), which may providea useful reference for researchers in this field.
