Serum nitric oxide content in adult patients with Kaschin-Beck disease: A Meta-analysis
10.3760/cma.j.cn231583-20190321-00068
- VernacularTitle:成人大骨节病患者血清一氧化氮含量变化的Meta分析
- Author:
Mingjun WANG
1
;
Qiang ZHANG
;
Hong JIANG
;
Jing MA
;
Yanan LI
;
Xun CHEN
;
Hongting SHEN
;
Guanglan PU
;
Duolong HE
Author Information
1. 青海省地方病预防控制所地方病预防控制科，西宁 811602
- From:
Chinese Journal of Endemiology
2020;39(6):447-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the changes of serum nitric oxide (NO) content in adult patients with Kaschin-Beck disease (KBD).Methods:Systematic retrieval was conducted on China National Knowledge Infrastructure (CNKI), WanFang Data, VIP Database, PubMed, Embase and other databases, to analyze the literatures published from the database establishment to March 31, 2019, on the changes of serum NO content of adult patients with KBD. Meta-analysis was performed using Revman 5.3 software, and mean difference ( MD) and 95% confidence interval ( CI) were calculated; sensitivity analysis was performed using fixed-effect model or random-effect model based on heterogeneity results; and publication bias was evaluated using funnel chart. Results:Totally 7 qualified literatures were included, including 358 cases in the adult KBD group and 305 cases in the control group. After the heterogeneity test, there was heterogeneity among the literatures (χ 2 = 188.07, I2 = 97%, P < 0.01), so a random-effect model was used for Meta-analysis. The NO content in the KBD group was significantly higher than that in the control group (MD = 44.29, 95% CI: 30.57 - 58.00), the difference was statistically significant ( Z = 6.33, P < 0.01). Sensitivity analysis showed that the results of this study were stable. The two sides of the funnel were basically symmetrical, suggesting that the possibility of publication bias was small. Conclusion:The serum level of NO content in adult patients with KBD is significantly increased.
