Research progress on the relationship between microRNA and imbalance of bone turnover in skeletal fluorosis
10.3760/cma.j.cn231583-20191231-00374
- VernacularTitle:微小RNA与氟骨症骨转换关系的研究进展
- Author:
Ning GUO
1
;
Yanhui GAO
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心地氟病防治研究所 150081
- From:
Chinese Journal of Endemiology
2020;39(4):299-304
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal fluorosis is an endemic disease prevalent in many countries in the world. China is one of the countries most affected by endemic fluorosis. The typical pathological change of skeletal fluorosis is accelerated bone turnover in bone tissue, during which a large number of transcription factors, signaling proteins and signaling pathways are expressed abnormally. However, the specific mechanism is not completely clear. MicroRNAs (miRNAs) are single-stranded non-coding RNA molecules involved in post-transcriptional regulation of genes. Studies have shown that miRNA can regulate the proliferation and differentiation of osteoblasts and osteoclasts, and is an important regulator of biological organ development and bone metabolic diseases. In this paper, the possible role of miRNA in the occurrence and development of skeletal fluorosis was discussed to provide ideas and directions for further study on the pathogenesis of skeletal fluorosis.
