Potential link between fluorosis neurological injury and endoplasmic reticulum stress
10.3760/cma.j.cn231583-20190710-00195
- VernacularTitle:氟中毒对神经系统的损伤及与内质网应激潜在因素的联系
- Author:
Shiwen TAN
1
;
Wei WEI
;
Dianjun SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心地氟病防治研究所 国家卫健委病因流行病学重点实验室 黑龙江省普通高校病因流行病学重点实验室 150081
- From:
Chinese Journal of Endemiology
2020;39(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum stress (ERS) is an important defense mechanism. Under the stimulation of various physical and chemical factors, cells respond to a series of signal transduction pathways to determine whether cells are adapted or not. Fluoride can cause impairment to the nervous system of the body, leading to learning, memory and cognitive impairment, but its mechanism is unknown. Studies have shown that the mechanism of fluorosis damage may be related to ERS-mediated apoptosis. In recent years, nervous system injury caused by fluorosis has been widely concerned by researchers, and ERS may play an important role in its mechanism. Therefore, this article will comprehensively explain the possible role of ERS in nervous system injury caused by fluorosis, and provide a new idea for elucidating the pathogenesis of fluorosis.
