The role of Nrf2 and its mediated adaptive antioxidant response in arsenic carcinogenesis
10.3760/cma.j.issn.2095-4255.2020.01.015
- VernacularTitle:Nrf2及其介导的适应性抗氧化反应在砷致癌效应中的作用
- Author:
Shimin CHEN
1
;
Xiaohang XU
;
Yuanyuan XU
Author Information
1. 中国医科大学公共卫生学院慢病环境基因组学研究室，辽宁沈阳 110122
- From:
Chinese Journal of Endemiology
2020;39(1):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is a systemic poison ubiquitously distributed in the nature. Long-term arsenic exposure can lead to a variety of cancers. Oxidative stress is a well-recognized mechanism underlying arsenic carcinogenesis. Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor in cellular antioxidant defense. However, accumulating evidences suggest that environmental arsenic exposure may cause and promote arsenic-related cancers through Nrf2-mediated adaptive antioxidant response, which constitutively induces the expression of antioxidant enzymes and detoxification enzymes and confers survival advantage to the cell under stress. Therefore, elucidating the role of Nrf2 and its medicated antioxidant response in arsenic carcinogenesis is vital to prevention and treatment of cancers related to arsenic exposure.
