Fluorescent antibiotics for real-time tracking of pathogenic bacteria
- Author:
Lu MIAO
1
;
Weiwei LIU
;
Qinglong QIAO
;
Xiaolian LI
;
Zhaochao XU
Author Information
1. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China
- Keywords:
Fluorescent antibiotics;
Live-cell tracking;
Fluorophore;
Pathogenic bacteria;
Fluorescent imaging
- From:
Journal of Pharmaceutical Analysis
2020;10(5):444-451
- CountryChina
- Language:Chinese
-
Abstract:
The harm of pathogenic bacteria to humans has promoted extensive research on physiological processes of pathogens, such as the mechanism of bacterial infection, antibiotic mode of action, and bacterial antimicrobial resistance. Most of these processes can be better investigated by timely tracking of fluorophore-derived antibiotics in living cells. In this paper, we will review the recent development of fluorescent antibiotics featuring the conjugation with various fluorophores, and focus on their applica-tions in fluorescent imaging and real-time detection for various physiological processes of bacteria in vivo.
