Prognostic value of albumin to globulin ratio combined with prognostic nutritional index in patients with resectable gastric cancer
10.3760/cma.j.cn115455-20200630-00816
- VernacularTitle:白蛋白与球蛋白比值联合预后营养指数对可切除胃癌患者预后的预测价值
- Author:
Cuihua WU
1
;
Jie YANG
;
Hui FAN
Author Information
1. 南通大学附属如皋医院肿瘤科，江苏如皋 226500
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(12):1060-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic value of albumin to globulin ratio (AGR) combined with prognostic nutrition index (PNI) in patients with resectable gastric cancer (rGC).Methods:From January 2015 to December 2017, 158 patients with rGC who underwent radical gastrectomy in Rugao Hospital were included, and followed up until May 2020 or died. The preoperative AGR and PNI were calculated. The cut-off value of AGR and PNI were determined by receiver operating characteristic (ROC) curve. The relationship between AGR-PNI and clinicopathological indicators were analyzed. The Kaplan-Meier method was used to calculate the cumulative overall survival rate. Log-rank test and univariate prognostic analysis were used. The Cox proportional hazards regression model was used for multivariate prognostic analysis.Results:The cut-off value of ROC curve of AGR and PNI were 1.19 and 43.70 respectively. The area under ROC curve (AUC) of AGR-PNI was larger than that of AGR and PNI ( Z = 2.596, P = 0.009; Z = 2.403, P = 0.016). Patients were divided into three groups: group 0 (AGR ≥ 1.19, PNI ≥ 43.70; 75 cases), group 1 (AGR ≥ 1.19, PNI < 43.70, or AGR < 1.19, PNI ≥ 43.70; 55 cases), group 2 (AGR <1.19, PNI < 43.70; 28 cases). The age, sex, tumor diameter, TNM stage and degree of tissue differentiation were significantly different among three groups ( P < 0.05). The results of multivariate analysis showed that age (≥ 60 years old vs. < 60 years old, HR = 1.878, 95% CI1.011-3.491, P = 0.046), TNM stage (Ⅲ stage vs. Ⅰ stage, HR = 2.148, 95% CI 1.074-4.296, P = 0.031), degree of tissue differentiation (moderate or good vs. poor, HR = 0.399, 95% CI 0.211-0.753, P = 0.005), AGR-PNI (group 2 vs. group 0, HR = 2.729, 95% CI 1.303-5.715, P = 0.008) were independent risk factors for survival of patients with rGC. Conclusions:AGR-PNI can be used as an effective predictor of the prognosis of rGC patients, and high grouping indicates poor prognosis.
