The mid-term efficacy of sodium tanshinone ⅡA sulfonate injection combined with clopidogrel in the treatment of angina pectoris and its effect on vascular endothelial function and micro-inflammatory state
10.3760/cma.j.cn115455-20200213-00134
- VernacularTitle:丹参酮Ⅱ A磺酸钠注射液联合氯吡格雷治疗冠心病心绞痛的中期疗效及对血管内皮功能和微炎性反应状态的影响
- Author:
Jumei YANG
1
;
Songquan KONG
Author Information
1. 浙江省磐安县人民医院中药房 322300
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(10):944-948
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the mid-term efficacy of sodium tanshinone ⅡA sulfonate injection combined with clopidogrel in the treatment of angina pectoris and its effect on vascular endothelial function and micro-inflammatory state.Methods:One hundred patients with coronary heart disease and angina pectoris admitted to Pan′an County People′s Hospital from June 2015 to June 2019 were divided into two groups according treatment methods, with 50 patients in each group. On the basis of conventional symptomatic treatment, test group was given clopidogrel (75 mg once a day) combined with sodium tanshinone ⅡA sulfonate injection. In control group , clopidogrel (75 mg once a day) and aspirin (150 mg once a day) were given. One cycle was four weeks. The expression levels of vascular endothelial-associated cytokines and peripheral blood CD 4+Foxp3 + Treg cells were detected and compared between the two groups. Results:The frequency and duration of angina pectoris before treatment in two groups had no significant differences ( P>0.05); after treatment, the frequency and duration of angina pectoris significantly decreased in the two groups ( P<0.05), the levels of frequency and duration of angina pectoris in test group were lower than those in control group [(0.4 ± 0.1) times/d vs. (0.6 ± 0.2) times/d , (3.4 ± 1.2) times/d vs. (5.8 ± 1.2) times/d, and there were significant differences ( P<0.05). The total effective rate in two groups had no statistical significance [98.0%(49/50) vs. 92.0%(46/50)]( P>0.05). Before treatment, the levels of nitric oxide (NO), endothelin (ET), thrombomodulin (TM) and CD 4+Foxp 3+ Treg in two groups had no significant differences ( P>0.05). After treatment, the levels of NO, TM in two groups increased and the levels of ET, CD 4+Foxp 3+ Treg in two groups decreased, and there were significant differences ( P<0.05). The levels of NO, TM in test group were higher than those in control group [(82.5 ± 5.1) ng/L vs. (71.9 ± 4.) ng/L, (32.4 ± 3.6) μmol/L vs. (25.2 ± 3.6) μmol/L], the levels of ET, CD 4+Foxp 3+ Treg in test group were lower than those in control group [(39.4 ± 5.2) μmol/L vs. (46.7 ± 5.4) μmol/L, (9.4 ± 1.8)% vs. (10.6 ± 1.7)%], and there were significant differences ( P<0.05). Conclusions:Sodium tanshinone ⅡA sulfonate injection combined with clopidogrel in the treatment of angina pectoris can improve cardiovascular endothelial function, inhibit myocardial inflammation and immune response.
