Analysis of clinical characteristics of rare variant Guillain-Barre syndrome
10.3760/cma.j.cn115455-20200310-00271
- VernacularTitle:少见变异型吉兰-巴雷综合征临床特点分析
- Author:
Hui ZHANG
1
;
Nianlong SUN
;
Jian DENG
;
Jing HAN
;
Ting RAO
;
Yitao HE
Author Information
1. 深圳市人民医院（暨南大学第二临床医学院、南方科技大学第一附属医院）神经内科 518020
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(6):492-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To introduce some rare clinical features of the variant Guillain-barre syndrome (GBS) and to explore its possible pathogenesis for the early diagnosis.Methods:The clinical data, laboratory data and treatment outcomes of four patients, who admitted to Shenzhen People′s Hospital from October 2017 to June 2018 and diagnosed with variant GBS were analyzed and summarized.Results:All the four patients presented limb weakness as a first manifestation. However, they all had clinical features that were inconsistent with typical GBS, and the clinical features were shown differently in each patient. One patient showed asymmetrical limb paralysis. The first manifestation of one patient was severe and persistent back pain accompanied by paraplegia. One patient was accompanied by obvious headache and positive meningeal irritation. One patients had the plane of sensory obstacles, paraplegia, and positive pathological sign. Cerebrospinal fluid examination showed protein cell dissociation in four patients. Electromyogram was consistent with peripheral neurogenic damage. Magnetic resonance imaging (MRI) of the brain and the spinal cord showed no obvious abnormalities. The four patients with obvious improvement in symptoms were treated with gamma globulin and glucocorticoid.Conclusions:Variant GBS is rare and clinical symptoms are various. Patients with atypical clinical symptoms should still be diagnosed by relevant auxiliary examinations to avoid delayed illness.
