Comparison of GP and TP regimens in the treatment of recurrent or metastatic nasopharyngeal carcinoma and their effects on the serum epithelial cadherin and platelet-derived growth factor levels
10.3760/cma.j.issn.1673-4904.2020.03.002
- VernacularTitle:两种方案治疗复发或转移性鼻咽癌的疗效对比及对血清上皮型钙黏蛋白、血小板源性生长因子水平的影响
- Author:
Weiyi DU
1
;
Shulian CHEN
;
Guoqiang LI
;
Zhengchao LI
;
Bin LI
;
Shengkai SUN
Author Information
1. 河北省秦皇岛市海港医院肿瘤科 066000
- Keywords:
Cisplatin;
Nasopharyngeal neoplasms;
Recurrence;
Gemcitabine;
Paclitaxel
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(3):198-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of gemcitabine plus cisplatin (GP) regimen and paclitaxel plus cisplatin (TP) regimen in the treatment of recurrent or metastatic nasopharyngeal carcinoma.Methods One hundred and thirty patients with recurrent or metastatic nasopharyngeal carcinoma of Qinhuangdao Harbor Hospital,Hebei Province between September 2012 and December 2017 were chosen,and were divided into GP group (68 cases) and TP group (62 cases)according to the selection of treatment.GP group was treated with GP regimen,and TP group was treated with TP regimen.The clinical efficacy and adverse reactions of the two groups were observed,and the serum epithelial cadherin (SE-CAD) and platelet-derived growth factor (PDGF-BB) were measured before and after chemotherapy.Results There was no significant difference in short-term efficacy between GP group and TP group (P＞0.05),and the total effective rates were 88.24％ (60/68) and 79.03％ (49/62) respectively;1 month after treatment,SE-CAD in GP group and TP group were (2.57 ± 0.81) and (2.50 ± 0.96) g/L,PDGF-BB were (102.22 ± 31.18) and (110.15 ± 37.21) ng/L,and the difference was not statistically significant (P＞0.05);progression-free survival (PFS) in GP group and TP group were 13 and 12 months,and overall survival (OS) were 17 and 16 months,and the difference was not statistically significant (P＞0.05);there were no significant difference in leucopenia,hemoglobin,thrombocytopenia and abnormal liver and kidney function between GP group and TP group (P＞0.05);the incidence of gastrointestinal reactions in GP group was 16.18％ (11/68),which was significantly lower than that in TP group was 38.71％(24/62),and the difference was statistically significant (P＜0.01).Conclusions GP and TP regimens are effective in the treatment of recurrent or metastatic nasopharyngeal carcinoma.There is no significant difference in SE-CAD and PDGF-BB levels between the two regimens after treatment,but GP regimen has a lower incidence of gastrointestinal reactions.
