Current research and challenge of human retinal organoid differentiation
10.3760/cma.j.cn115989-20200721-00518
- VernacularTitle:人视网膜类器官培养技术的进步与挑战
- Author:
Ziming LUO
1
;
Jian GE
Author Information
1. 中山大学中山眼科中心 眼科学国家重点实验室 广东省眼科及视觉科学重点实验室，广州 510060；School of Medicine, Stanford University, Palo Alto, CA, USA, 94304
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(10):809-812
- CountryChina
- Language:Chinese
-
Abstract:
The retinal organoid is one of the most widely studied organoids in vitro, which is an "organ in a dish" with a highly similar tissue structure to those in vivo.Since it was first reported, the differentiation methods of retinal organoids have been continously developed to improve the differentiation efficiency and achieve further maturation.Retinal organoids have a broad application prospect as developmental and disease models, as well as seed cells for replacement therapy.However, there are still some problems to be solved, including the universality, effectiveness, heterogeneity of retinal organoid differentiation, as well as the difference between retinal organoids development and the real fetal retinal development.Researchers should investigate the regulational mechanism during organoid development from molecular, genetic, cellular and histological structure levels in order to promote the clinical practices of organoid culture technology.
