Association of TLR4 polymorphisms with primary open angle glaucoma in Chinese population
10.3760/cma.j.cn115989-20191120-00505
- VernacularTitle:TLR4基因单核苷酸多态性与中国汉族人群原发性开角型青光眼关联研究
- Author:
Yi SHU
1
;
Jiaxin XU
;
Chen YANG
;
Yilian CHEN
;
Qian LUO
;
Bo GONG
;
Zhenglin YANG
;
Guo HUANG
Author Information
1. 成都中医药大学医学技术学院 610075
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(8):659-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect whether Toll-like receptor 4 ( TLR4) polymorphisms contributed to primary open angle glaucoma (POAG) in a Chinese population. Methods:A Chinese cohort, including 799 unrelated POAG patients and 799 unrelated controls, was enrolled in our case-control association study. The data was collected at Sichuan Provincial People's Hospital from May 2014 to March 2018. TLR4 functional single nucleotide polymorphisms (SNPs), including rs4986790 and rs4986791, were genotyped by SNaPshot method. Genotype and allele frequencies of the two SNPs were evaluated. This study was approved by the Institutional Review Boards of the Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (No.2016-58), and complied with the guidelines of the Declaration of Helsinki. Written informed consents were obtained from all subjects prior to the study. Results:Allelic association analysis revealed that there were no significant association detected in the allelic distributions between the POAG cases and controls for SNPs rs4986790 ( P=0.317) and rs4986791 ( OR=1.000, 95% CI =0.062 5-16.002 2, P=1.000) in the TLR4 gene. Conditional analysis of the two SNPs did not show any significant difference in genotype and allele frequency between the case and the control groups. No association of the two SNPs with POAG was detected under four different genetic models, including homozygote, heterozygote, dominant and recessive models. Conclusions:Polymorphisms rs4986790 and rs4986791 in the TLR4 gene are not related to POAG in the Chinese cohort.
