Review and analysis on knockout mouse models with cataract
10.3760/cma.j.cn115989-20190227-00087
- VernacularTitle:基因敲除白内障小鼠模型回顾及分析
- Author:
Zehua WU
1
;
Xiangyuan LIU
;
Yuying LI
;
Zilin ZHONG
;
Jianjun CHEN
Author Information
1. 同济大学医学院附属上海市第四人民医院脑功能与人工智能转化研究所，上海 200081
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(8):710-714
- CountryChina
- Language:Chinese
-
Abstract:
Cataract is the leading cause of blindness worldwide, which is a generally clinical and genetic heterogeneity eye disease.To date, more than 50 genes have been reported to be associated with congenital cataract.While for mouse, parts of human cataract related genes knockout mouse can also resulted cataract.As we know, the model of cataract related gene knockout mice can help us to understand the phenotype, pathogenesis, progress and prognosis of human cataract and it can also help to find unknow genes that not reported in human cataract yet.In this review, knockout mouse models with cataract are summarized, which can help to facilitate identification of cataract genes and clarification of the mechanisms of cataractgenisis.
