Association between MeCP2 and proliferative vitreoretinopathy under the regulation of tumor necrosis factor
10.3760/cma.j.cn115989-20191111-00491
- VernacularTitle:肿瘤坏死因子调控下MeCP2与增生性玻璃体视网膜病变发病的关联
- Author:
Yuejuan XU
1
;
Xiaohua LI
Author Information
1. 河南省人民医院眼科 河南省立眼科医院 河南省眼科研究所 河南省眼科与视觉科学重点实验室 河南大学人民医院 郑州大学人民医院 450003
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(6):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Proliferative vitreoretinopathy (PVR) is an ocular fundus disease involving multiple cytokines.Its important pathological process is epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells.Tumor necrosis factor (TNF) is an important inflammatory response inducing factor, which can be produced by activated RPE cells, microglia, monocytes and macrophages, and then participate in the occurrence and development of PVR.In addition to cytokines, epigenetic factors such as DNA methylation also play an important role in the development of PVR, in which methyl-CpG binding protein 2(MeCP2) is involved in EMT and fibrosis, and is highly expressed in PVR membrane.The positive expression of MeCP2 is also found in transformed RPE cells and microglia.It is speculated that MeCP2 plays an important role in the occurrence and development of PVR.TNF can also stimulate the expression of MeCP2.This article reviews the role of MeCP2 and the interaction between TNF and MeCP2 in the formation of PVR.
